Pemphigus

Pemphigus

OVERVIEW

Pemphigus is a disease that causes blisters and sores on the skin or mucous membranes, such as in the mouth or on the genitals.

Pemphigus can occur at any age, but it's most often seen in people who are middle-aged or older. It tends to be a long-lasting (chronic) condition, and some types can be life-threatening without treatment. Treatment with medication usually controls it.

Symptoms

Pemphigus causes blisters on your skin and mucous membranes. The blisters rupture easily, leaving open sores, which may ooze and become infected.

The signs and symptoms of two common types of pemphigus are as follows:

Pemphigus vulgaris. This type usually begins with blisters in your mouth and then on your skin or genital mucous membranes. The blisters typically are painful but don't itch. Blisters in your mouth or throat may make it hard to swallow and eat.

Pemphigus foliaceus. This type causes blisters on the chest, back and shoulders. The blisters tend to be more itchy than painful. Pemphigus foliaceus doesn't cause mouth blisters.

Pemphigus is distinct from bullous pemphigoid, which is a blistering skin condition that affects older adults and may cause death.

Causes

Pemphigus is an autoimmune disorder. Normally, your immune system produces antibodies to fight off harmful invaders, such viruses and bacteria. But in pemphigus, the body produces antibodies that damage cells of your skin and mucous membranes.

Pemphigus isn't contagious. In most cases, it's unknown what triggers the disease.

Rarely, pemphigus is triggered by the use of angiotensin-converting enzyme inhibitors, penicillamine and other drugs.

Risk factors

Your risk of pemphigus increases if you're middle-aged or older. The condition tends to be more common in people of Middle Eastern or Jewish descent.

Complications

Possible complications of pemphigus include:

Infection of your skin

Infection that spreads to your bloodstream (sepsis)

Malnutrition, because painful mouth sores make it difficult to eat

Medication side effects, such as high blood pressure and infection

Death, if certain types of pemphigus are left untreated

Diagnosis

Blisters occur with a number of more common conditions, so pemphigus, which is rare, can be difficult to diagnose. Your doctor may refer you to a specialist in skin conditions (dermatologist).

Your doctor will talk with you about your medical history and examine your skin and mouth. In addition, you may undergo tests, including:

A skin biopsy. In this test, a piece of tissue from a blister is removed and examined under a microscope.

Blood tests. One purpose of these tests is to detect and identify antibodies in your blood that are known to be present with pemphigus.

An endoscopy. If you have pemphigus vulgaris, your doctor may have you undergo endoscopy to check for sores in the throat. This procedure involves inserting a flexible tube (endoscope) down your throat.

TREATMENT 

Treatment usually begins with medications that are intended to suppress blister formation. It's generally more effective when it begins as early as possible. If use of a drug triggered your condition, stopping use of it may be enough to clear up your pemphigus.

Medications

The following prescription medications may be used alone or in combination, depending on the type and severity of your pemphigus and whether you have other medical conditions:

Corticosteroids. For people with mild disease, corticosteroid cream may be enough to control it. For others, the mainstay of treatment is an oral corticosteroid, such as prednisone pills.

Using corticosteroids for a long time or in high doses may cause serious side effects, including diabetes, bone loss, an increased risk of infection, stomach ulcers and a redistribution of body fat, leading to a round face (moon face).

Steroid-sparing immunosuppressant drugs. Medications such as azathioprine (Imuran, Azasan), mycophenolate (Cellcept) and cyclophosphamide help keep your immune system from attacking healthy tissue. They may have serious side effects, including increased risk of infection.

Other medications. If first-line drugs aren't helping you, your doctor may suggest another drug, such as dapsone, intravenous immunoglobulin or rituximab.

Many people get better with treatment, although it may take years. Others need to take a lower dose of medication indefinitely to prevent their signs and symptoms from returning. And some people need treatment in a hospital — for example, to care for severe or infected sores.

TYPE OF DOCTOR DEPARTMENT :- Dermatology SPECIALIST CAN DIAGNOSES THIS DISEASE.