Health and Fitness

Musculoskeletal tumors  Overview Musculoskeletal tumors are abnormal growths that start in bones, muscles, fat, blood vessels, or other supporting tissues. They can be benign (non-cancerous) or malignant (cancerous, often called sarcomas). Symptoms Deep Pain: Aching discomfort in a bone or muscle that does not go away with rest or standard pain relievers. Swelling and Masses : A growing lump under the skin that may feel soft, firm, or warm to the touch. Limited Movement: Stiffness, a limp, or trouble moving a nearby joint freely.Weakened Bones: Fractures happening with little to no obvious cause. General Fatigue: Feeling very tired, running a low fever, or losing weight unexpectedly. Causes Inherited gene changes: Syndromes like Li-Fraumeni syndrome, neurofibromatosis, and retinoblastoma raise your risk. Past radiation therapy : High doses of radiation used to treat prior cancers can damage cell DNA over time. Rapid bone growth: Tumors like osteosarcoma often show up during te...

ALG12-congenital disorder of glycosylation Overview ALG12-congential disorder of glycosylation (ALG12-CDG) is a rare, inherited multi-system condition caused by mutations in the ALG12 Gene, leading to intellectual disability, weak muscle tone, and immune issues Symptoms Growth and Neurological Signs Failure to thrive : Feeding difficulties and trouble gaining weight. Hypotonia: Weak or low muscle tone. Developmental delay: Delayed motor skills and moderate-to-severe intellectual disability. Seizures: Developing in some affected individuals.Microcephaly: Progressive small head size. Physical and Facial Features Facial dysmorphism: Prominent nasal bridge or forehead, epicanthal eye folds, and abnormally shaped or large ears. Skeletal abnormalities: Poor bone development and abnormal bone ossification. Genital abnormalities: Micropenis and undescended testes (cryptorchidism) in males. Immune and Other Complications Low antibodies: Hypogammaglobulinemia (reduced immunoglobulin G/IgG ...

Aldosterone-producing adenoma Overview An aldosterone-producing adenoma (also called Conn's adenoma or aldosteronoma) is a benign tumor in an adrenal gland that overproduces the hormone aldosterone. This excess hormone causes primary hyperaldosteronism, leading to high blood pressure, low potassium levels, muscle weakness, and increased risk of heart problems. Symptoms People with an aldosteronoma typically have high blood pressure, but most don’t have any other symptoms. When low potassium levels result, however, people may experience one or more of the following symptoms related to their aldosteronoma: Muscle weakness or, rarely, episodes of muscle paralysis Muscle spasms and/or cramps Fatigue Headache Excessive thirst Excessive or frequent urination Waking up at night to urinate Numbness and/or tingling of hands and feet Causes Effects and Body Changes High blood pressure: Extra salt and water stay in the body, which raises blood pressure. Low potassium (hypokalemia): The kidn...

Fundus albipunctatus Overview Fundus albipunctatus is a rare, inherited eye disorder causing stationary night blindness and small whitish-yellow retinal flecks, primarily linked to mutations in the [RDH5 gene] (https://medlineplus.gov/genetics/condition/fundus-albipunctatus/). It features delayed dark adaptation and normal daytime vision. Symptoms Primary Vision Symptoms Night blindness : Trouble seeing clearly or moving around safely in dim light or at night, usually starting in early childhood. Slow dark adaptation: Severe delay in adjusting vision when moving from bright sunlight into a dark space (like walking into a dark room or driving into a tunnel), which can take hours instead of minutes. Normal bright light vision: Clear daytime visual acuity and normal side (peripheral) vision during standard conditions. Physical Eye Findings Retinal flecks: Countless tiny, round, white or yellowish-white spots scattered across the retina while sparing the central fovea region. Fading spot...

Gastroesophageal reflux disease (GERD) Overview Gastroesophageal reflux disease happens when stomach acid flows back up into the esophagus and causes heartburn. It's often called GERD for short. This backwash is known as acid reflux, and it can irritate the lining of the esophagus. Many people experience acid reflux now and then. However, when acid reflux happens repeatedly over time, it can cause GERD. Most people can manage the discomfort of GERD with lifestyle changes and medicines. And though it's uncommon, some may need surgery to help with symptoms. Symptoms Common symptoms of GERD include: A burning sensation in the chest, often called heartburn. Heartburn usually happens after eating and might be worse at night or while lying down. Backwash of food or sour liquid in the throat. Upper belly or chest pain. Trouble swallowing, called dysphagia. Sensation of a lump in the throat. If you have nighttime acid reflux, you also might experience: An ongoing cough. Inflammation of...

Crohn's disease Overview Crohn's disease is a type of inflammatory bowel disease (IBD) that causes swelling and irritation of the tissues, called inflammation, in the digestive tract. This can lead to belly pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can affect different areas of the digestive tract in different people. Crohn's most commonly affects the end of the small intestine and the beginning of the large intestine. The inflammation often spreads into the deeper layers of the bowel. Crohn's disease can be both painful and debilitating. Sometimes, it may lead to serious or life-threatening complications. There's no known cure for Crohn's disease, but therapies can greatly reduce its symptoms and even bring about long-term remission and healing of inflammation. With treatment, many people with Crohn's disease can function well. Symptoms Symptoms of Crohn's disease typically include: Diarrhea...