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Vogt-Koyanagi-Harada Disease (VKH

Vogt-Koyanagi-Harada Disease (VKH) Overview Vogt-Koyanagi-Harada disease (VKH) is a rare condition that causes inflammation and damage throughout your body. It’s also known as Vogt-Koyanagi-Harada syndrome. VKH disease can affect your: Eyes Inner ear Skin Hair Brain Spinal cord Vogt-Koyanagi-Harada can permanently damage your vision and hearing if it’s not treated quickly. Visit a healthcare provider or eye doctor if you notice any sudden changes. Symptoms VKH causes lots of symptoms. You’ll notice some right away. It usually affects both your eyes first. Vision changes are the first sign. Symptoms will appear in other parts of your body later. There are four phases: Prodromal phase Acute uveitic phase Chronic phase Recurrent chronic phase Prodromal phase Prodrome is the medical name for an early sign or symptom. This first phase of VKH disease is short. It usually lasts around a week. Symptoms in this phase often resemble a flu-like illness. They can include: Eye pain, especially pain...
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Diplegia

Diplegia Overview Diplegia is a form of paralysis or motor impairment affecting symmetrical body parts, most commonly both legs (spastic diplegia), though it can affect the arms or face. Often caused by cerebral palsy due to premature birth, it causes muscle stiffness and high tone (spasticity). While it affects mobility, it does not always impact intelligence. Symptoms Spasticity: Extremely tight, stiff muscles in the lower limbs, leading to limited movement.  Scissor   Gait: Legs turn inward, cross at the knees, or stiffen, making walking difficult. Toe  Walking: A tendency to walk on toes due to tightened calf muscles. Weakness in Legs: Difficulty holding up body weight.  Delayed Motor Milestones: Delays in sitting, crawling, or walking (often walking is delayed until ages 2–4). Muscle/Joint Issues : Permanent contractures (shortening of muscles), joint deformities, and hip displacement. Balance/Posture Issues : Difficulty with coordination and maintaining po...
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Monoplegia

  Monoplegia Overview What is monoplegia? Monoplegia occurs when something, like a stroke or an injury, disrupts the nerve signals to the muscles in your arm or leg. It’s a type of paralysis that affects one arm or leg. Paralysis means you can’t move a part of your body. Monoplegia is sometimes temporary, but it’s often permanent. A problem with your nervous system causes monoplegia. Your nervous system is your body’s command and communication system. It sends signals from your brain throughout your body, telling it what to do. If something damages your nervous system, messages can’t get through to the muscles in your arm or leg. The message has to go from your brain to your spinal cord, nerve roots, nerves and then your muscles. So, there are a lot of places that monoplegia could come from. Symptoms The inability to move one of your arms or legs is the most common symptom of monoplegia. Other symptoms that happen with monoplegia that may affect your arm or leg include: Curling of ...
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Hemiplegia

Hemiplegia Overview Hemiplegia is paralysis that affects only one side of your body. This symptom is often a key indicator of severe or life-threatening conditions like a stroke, but can also happen with conditions and circumstances that aren’t as dangerous. Hemiplegia is paralysis, which means you can’t move or control the muscles in the affected body part. That can cause muscles that are completely limp. It can also cause spastic hemiplegia, a type of paralysis where muscles contract uncontrollably. Hemiplegia affects either the right side of your body (right hemiplegia) or the left side of your body (left hemiplegia), with your spine (backbone) being the dividing line between the two halves. Hemiplegia may affect your face, arm and leg on one side of your body in various ways: The paralysis may not be present, or not be as severe in all of these three body areas. There are even some rare conditions that cause hemiplegia to come and go, affecting one or both sides of the body as it d...
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Quadriplegia

Quadriplegia Overview Quadriplegia is a pattern of paralysis — which is when you can’t deliberately control or move your muscles — that can affect a person from the neck down. Depending on how and why it happens, it can affect your ability to move parts of your body, as well as some of your body’s automatic processes that keep you alive. Quadriplegia (also known as tetraplegia; see below for an explanation of these terms) is usually a symptom of other problems, but there are some instances where it’s a standalone condition. Overall, quadriplegia is the most common symptom of traumatic spinal cord injury, happening in about 60% of cases. There are also two main ways, complete and incomplete, that quadriplegia can happen. Incomplete quadriplegia . This means that the quadriplegia blocks some — but not all — signals from getting through. That means a person might still have some ability to move, feel sensations or control automatic body processes (such as bowel and bladder function). This...
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Walking pneumonia

Walking pneumonia Overview Walking pneumonia is a mild form of pneumonia. Pneumonia is a lung infection that causes your airways to swell, the air sacs in your lungs to fill with mucus and other fluids, a high fever and a cough with mucus. If you have walking pneumonia, you may feel well enough to walk around and carry out daily tasks without realizing you have pneumonia. “Walking pneumonia” is the common term for atypical pneumonia. Who does walking pneumonia affect? Anyone can get walking pneumonia. You’re more likely to get walking pneumonia if you: Are 2 or younger. Are 65 or older. Have a weakened immune system (immunocompromised) or take immunosuppressant medications. Have chronic obstructive pulmonary disease (COPD). Have asthma. Have emphysema. Live or work in crowded places, such as schools, dormitories, nursing homes or military barracks. Use tobacco products. Regularly use inhaled corticosteroids. Symptoms Walking pneumonia symptoms include: Sore throat (pharyngitis). Extrem...
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Vitamin B12 transport defects

Vitamin B12 transport defects Overview Vitamin B12 transport defects are rare congenital disorders, such as Transcobalamin II (TC II) deficiency, that prevent cobalamin from reaching tissues, causing severe cellular deficiency despite normal serum B12 levels. These genetic conditions lead to megaloblastic anemia, developmental delay, and neurological issues in infants, often requiring lifelong treatment. Symptoms Neurological Symptoms (Severe): Developmental delays, ataxia (difficulty walking), tremor, convulsions, hypotonia (weak muscle tone), and tingling or numbness (paresthesia). Hematological Issues: Megaloblastic anemia, causing profound fatigue, weakness, dizziness, and pale or yellowish skin. Gastrointestinal Distress: Persistent vomiting, diarrhea, and failure to gain weight/grow properly in infants. Mucosal and Skin Issues : Sore mouth or tongue (glossitis), skin hyperpigmentation, and dermatitis. Psychological Changes: Irritability, confusion, and potential cognitive decl...
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