Overview Compartment syndrome occurs when pressure rises in and around muscles. The pressure is painful and can be dangerous. Compartment syndrome can limit the flow of blood, oxygen and nutrients to muscles and nerves. It can cause serious damage and possible death. Compartment syndrome occurs most often in the lower leg. What is a compartment? A compartment is a group of muscles, nerves and blood vessels. A thin but firm membrane (covering) called a fascia lies over each compartment. It keeps the muscles in place. But the fascia isn’t meant to stretch or expand much. What causes compartment syndrome? A serious injury or too much physical exertion can cause swelling or bleeding in a compartment. The fascia won’t expand to make room, so the swelling or bleeding puts pressure on the nerves and muscles. Healthcare providers call this compartmental pressure. If the pressure gets too high, the tissues can’t get enough blood, which contains oxygen and nutrients. The tissues can die, leading...