Enthesitis-Related Arthritis Enthesitis-related arthritis (ERA) is one of several types of juvenile idiopathic arthritis (JIA). These childhood autoimmune conditions begin before the child’s 16th birthday and can evolve, flare, or improve over time. Enthesitis is the painful inflammation of the entheses, the fibrous connective tissue that attaches your tendons and ligaments to your bones. There are over 100 entheses in your body. In ERA, your immune system mistakenly attacks both joints and entheses, leading to inflammation. Children with ERA may have swelling, pain, and stiffness of multiple joints and entheses, along with other symptoms. Although ERA is a chronic disease, treatment can manage symptoms and even cause them to go into remission. What are the symptoms of enthesitis-related arthritis? Common symptoms include: enthesitis (pain where tendons or ligaments join bones), m ost often at the lower part of the kneecap and the heel arthritis (pain, swelling, and stiffness) of ...