Kaposi's sarcoma Overview Kaposi sarcoma is a type of cancer that forms in the lining of blood vessels and lymph vessels. The cancer forms growths of cells, called lesions, on the skin. The lesions often form on the face, arms and legs. The lesions may look pink, red, purple or brown. Lesions also can appear on the genitals or in the mouth. In severe Kaposi sarcoma, lesions can be in the digestive tract and lungs. The cause of Kaposi sarcoma is infection with the virus human herpes virus 8, also called HHV-8. In healthy people, this infection usually causes no symptoms because the immune system keeps it under control. In someone with a weakened immune system, however, HHV-8 can lead to Kaposi sarcoma. Types of Kaposi sarcoma include: AIDS-related or epidemic Kaposi sarcoma. This type happens in people infected with human immunodeficiency virus, also called HIV. HIV is the virus that causes AIDS. Transplant-associated or iatrogenic Kaposi sarcoma. This type happens in people who ta...